Lithium Orotate Powder
Pure Lithium Orotate Powder for Your Emotional Wellness Products
- CAS Number: 5266-20-6
- EINECS Number: 226-081-4
- Molecular Weight: 164.05
- Molecular Formula: C5H5LiN2O4
- Chemical Name: Lithium Orotate
- Related Name: Lithium Monoorotate, Lithium Orotate Monohydrate, Lithium Salt of Orotic Acid, Orotic acid, lithium salt, Lithium (from Lithium Orotate), Lithium 2,4-dioxo-1H-pyrimidine-6-carboxylate
- Appearance: White to off-white crystalline powder
What Is Lithium Orotate Powder?
Lithium Orotate is a lithium-based nutritional ingredient combined with orotic acid. It is a combination of trace lithium with orotic acid. As a transport compound, orotic acid improves the efficiency of lithium crossing the blood-brain barrier. Therefore, Lithium Orotate can deliver cellular health benefits at a low and safe dosage.
Lithium Orotate is widely applied in nootropics and mood-support products.
Functions of Our Lithium Orotate Powder
Lithium Orotate powder maintains healthy cognitive performance by supporting synaptic plasticity and neuronal structure. It helps protect the brain cells from damage caused by cellular stress and excitotoxicity. In this way, it promotes mental focus, memory retention, and long-term brain vitality.
If you are developing a brain health product line or cognitive dietary supplements, we recommend applying high-purity Lithium Orotate powder to support long-term nerve vitality and mental clarity.
Lithium Orotate powder can adjust vital nerve pathways, including serotonin and dopamine signaling. This helps stabilize mood, reduces occasional irritability, and promotes overall mental resilience when handling daily pressure.
You can utilize it in your mood-balancing products and target the market for stress relief and emotional health.
Lithium Orotate can influence circadian gene expression and support the balance of internal body clock rhythms. It leads to a smooth sleep onset and deep restorative sleep phases. It promotes nighttime nerve recovery without causing drowsiness in the daytime.
If you are developing sleep-aid supplements or nighttime relaxation drink mixes, Lithium Orotate powder is an ideal ingredient. You can highlight the functions of encouraging restorative rest and natural sleep cycles during product promotion.
Lithium Orotate can promote the expression of neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF). This biological process helps with nerve recovery and renewal. It supports healthy aging formulations focused on maintaining normal neurological function.
You can apply it in your anti-aging supplements or longevity supplements for comprehensive nerve vitality protection.
More About Our Company
- Professional Lithium Orotate Powder Supplier
- Features
- Manufacturing
- Specification
- Over 10 years of experience in manufacturing Lithium Orotate powder
- 10-20g free sample available for R&D testing and verification
- Trusted by global customers in over 50 countries
- Reliable supply capacity for bulk orders in the long term
- Compliance with global market regulatory requirements
High Purity and Precise Active Content: Premium purity ≥ 98.5%. Stringently controlled heavy metals and residual solvents. Standardized elemental lithium ratio to ensure your final products are accurate in formula dosage and consistent across batches.
Superior Processing Adaptability: Excellent flowability and stable bulk density make our powder ideal for capsule filling, direct compression for tablets, and powder blending. Significantly reduce the risk of production line downtime and waste.
Scalable and Stable Supply: As a direct manufacturer, Sunjoy offers competitive direct-from-factory pricing. We have large-scale production capacity and stable production capacity and supply continuity to ensure fast delivery and fulfill your bulk orders in the long term.
Strict Consistency Across Batches: Sunjoy ensures the color and assay are constant across batches with our strict quality control processes. In this way, we minimize formula variation and re-testing risks in your final products.
Step 1: Prepare Raw Materials: We prepare the three raw materials: pure water, orotic acid, and lithium hydroxide. We use high-purity ingredients to ensure the high quality of our final product (Lithium Orotate Powder).
Step 2: Synthesis Reaction: We mix the orotic acid and lithium hydroxide thoroughly in pure water to trigger a synthesis reaction. This reaction yields lithium orotate.
Step 3: Filtration and Washing: When the reaction is over, we separate the solid Lithium orotate from the liquid by filtering. Then it undergoes the washing process to eliminate unreacted substances and residue.
Step 4: Drying and Milling: We remove the moisture from the purified wet product. After drying, it is milled into fine powder.
Step 5: Packaging: We pack the lithium orotate powder in a clean room. The powder is sealed in moisture-proof packaging for long-term storage.
| Production Flow Elements and Functions | ||
| Stage | Process / Element | Key Role / Key Attributes |
| Inputs | Raw Materials (Water, Orotic acid, LiOH) | Reaction foundation; pure precursors |
| Reaction | Synthesis | Chemical bonding; complex formation |
| Purification | Filtration & Washing | Solid-liquid separation; impurity removal |
| Refinement | Drying & Milling | Moisture elimination; powder formation |
| Product | Lithium Orotate Powder | Finished target compound; bioavailable complex |
| Fulfillment | Packaging | Physical sealing; moisture barrier; storage prep |
| Lithium Orotate Powder COA | |
| Analysis | Specification |
| Assay (Dry basis) | ≥98.50% |
| Lithium | 3.79~3.89% |
| State of solution | Clear and colorless |
| Heavy Metal (Pb) | <20 ppm |
| Chloride (Cl) | <100 ppm |
| Loss on drying | ≤0.50% |
| Appearance | White crystalline powder |
| Storage | Store in a well-closed place with constant low temperature and no direct sunlight. |
Related Products
β-Nicotinamide Mononucleotide Powder (NMN) can efficiently improve the level of NAD+. In this way, it helps with the recovery of cellular energy and DNA repair. Meanwhile, Lithium Orotate helps maintain the neurotransmitter balance and cellular brain health. It supports cognitive functions.
You can apply these ingredients together in your healthcare products and highlight the function of cellular anti-aging and brain health.
Pyrroloquinoline Quinone (PQQ) is a powerful mitochondrial energizer. It can activate the generation of mitochondria directly and promote mental focus. Lithium Orotate targets the neural signaling pathways in the brain. In this way, it protects the neurons from oxidative stress and damage from cognitive decline along with PQQ.
You can combine these two ingredients in your nootropic formulations and target consumers seeking long-term neuroprotection who require intense focus.
CoQ10 efficiently provides energy for cells and optimizes the energy generation of vital organs. While Lithium Orotate helps with mood stability to maintain overall nervous system health.
You can combine them in your dietary supplements and highlight the function of stress relief and energy booster in your product promotion.
Calcium L-5-Methyltetrahydrofolate is an active form of folate. It can directly participate in the methylation process and support the synthesis of neurotransmitters. While Lithium Orotate targets the neural pathways and mood health. They can coordinate to support mood stability and optimize brain functions.
You can combine them as a duo and apply them in your cognitive and mood health formulas. They are ideal for your potential consumers who care for daily mood balance and mental health support.
Lithium Orotate is the most suitable ingredient for your dietary supplements among these three ingredients. Because it is specifically designed for low-dose nutritional formulations.
Lithium Carbonate and Lithium Citrate are commonly applied in the pharmaceutical industry. They are used in the treatment of mental disorders, such as bipolar disorder. They have regulatory approval and decades of clinical research.
The table below showcases the differences between these three ingredients. If you have any questions about Lithium Orotate, feel free to contact our service team for more information.
| Lithium Orotate Powder vs. Pharma-Grade Lithium Salts | |||
| Feature / Ingredient | Lithium Orotate | Lithium Carbonate | Lithium Citrate |
| Primary Category | Nutraceutical / Dietary Supplement | Pharmaceutical Ingredient (API) | Pharmaceutical Ingredient (API) |
| Typical Application | Daily mood support, cognitive wellness | Treatment of bipolar disorder and mania | Treatment of bipolar disorder and mania |
| Formulation Type | Over-the-Counter (OTC) / Supplements | Prescription Medicine (Rx) | Prescription Medicine (Rx) / Liquid Form |
| Elemental Lithium Content | Low (about 3.8%) | High (about 18.8%) | Moderate (about 11.3%) |
| Bioavailability and Absorption | High cellular permeability; effective at low doses | Standard pharmaceutical absorption | Standard pharmaceutical absorption |
| Regulatory Status | Allowed in Dietary Supplements (Region dependent) | FDA-approved Prescription Drug | FDA-approved Prescription Drug |
| Market Suitability | Best for Supplement Brands | Clinical / Pharmaceutical Use Only | Clinical / Pharmaceutical Use Only |
The theoretical content of elemental lithium in pure Lithium Orotate is approximately 3.83%. For example, 130 mg Lithium Orotate powder provides about 5 mg active elemental lithium.
In dietary supplements, the recommended elemental lithium commonly ranges from 5 mg to 20 mg, which means 130 mg to 520 mg Lithium Orotate powder.
Lithium Orotate powder should be stored in cool, dry places and should avoid exposure to direct light and moisture. Seal the package each time after using it. Place it away from heat sources and keep it under 25 °C (77 °F).
Under proper storage conditions, the shelf life is over 24 months.
Sunjoy Lithium Orotate Powder adapts to multiple supplement manufacturing processes.
| Application and Dosage Form Compatibility | ||
| Dosage Form | Key Material Features | Target Applications |
| Hard Capsules and Tablets | High flowability | Direct compression |
| High compressibility | Dry granulation | |
| Low moisture absorption (Loss on drying≤0.50%) | Single-ingredient or blend encapsulations | |
| Powder Premixes and Nootropic Blends | Homogeneous blending capability | Multi-ingredient brain support powders |
| Low hygroscopicity | Stick packs and sachets | |
| High active ingredient stability | Custom dietary premixes | |
Here we list common contraindications when taking Lithium Orotate:
Diuretics
Also known as water pills. May cause dehydration and concentrate the lithium levels in the blood. Increase risk of accumulation and toxicity.
Non-Steroidal Anti-Inflammatory Drugs
NSAIDs like ibuprofen, aspirin, and naproxen can reduce kidney blood flow and clearance of lithium. May cause dangerously high levels in the bloodstream.
Blood Pressure Medications
ACE inhibitors like lisinopril can reduce kidney clearance of lithium and easily lead to toxic risks.
Antidepressants
SSRIs like fluoxetine, sertraline combined with Lithium Orotate may increase side effects in the nervous system and the risk of serotonin-related complications.
Alcohol
Alcohol can cause side effects such as dizziness and drowsiness, and may increase the risk of toxicity caused by dehydration.
Extreme Low-Sodium Diets
When the human body lacks sodium, the kidneys will retain more lithium and increase toxicity risks.
Contact Us
If you are searching for pure Lithium Orotate powder for your products, Sunjoy offers competitive pricing and a stable supply chain. Contact us today and get your free sample soon.
