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  • Bulk L-Glutathione Reduced 1
  • Bulk L-Glutathione Reduced 2
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  • Bulk L-Glutathione Reduced 1
  • Bulk L-Glutathione Reduced 2
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Bulk L-Glutathione Reduced

Pure L-Glutathione Reduced Powder for Your Cosmetic Products and Supplements

  • CAS Number: 70-18-8
  • EINECS Number: 200-725-4
  • Molecular Weight: 307.32
  • Molecular Formula: C10H17N3O6S
  • Chemical Name: L-Glutathione Reduced
  • INCI Name (Cosmetics): Glutathione
  • Related Name: glutathione, r-glutamyl cysteine + glycine, GSH, Reduced Glutathione
  • Appearance: white to off-white crystalline powder

What Is L-Glutathione Reduced?

L-Glutathione Reduced (GSH) is a vital antioxidant and enzyme cofactor that can promote metabolism and neutralize free radicals. It recycles Vitamin C to sustain the antioxidant network and protect cells from damage. 

GSH facilitates this through its active thiol (-SH) group. It protects enzyme proteins from losing their activity due to oxidants and adjusts signal pathways like NF-κB. In this way, GSH prevents premature cell death.

Based on these various physiological functions, GSH is widely applied in clinical medicine, anti-aging therapies, and dietary supplements to help with liver detoxification and cellular health of the whole body.

Functions of Our L-Glutathione Reduced

Skin Brightening

L-Glutathione Reduced powder brightens skin by directly inhibiting the activity of tyrosinase. It converts the melanin synthesis pathway from dark eumelanin to lighter pheomelanin. In this way, it helps improve the skin tone and reduce dark spots. 

GSH powder is commonly combined with Vitamin C and Vitamin E in brightening skincare formulations. Sunjoy provides all these three ingredients with high bioavailability and purity.  These skincare products have functions of maintaining skin elasticity and natural glow, preventing light-induced aging, and preserving a healthy skin structure.

Skin Brightening
Antioxidant

GSH powder can directly neutralize reactive oxygen species (ROS) and cellular peroxide waste. It protects key biological macromolecules from oxidative damage of oxidation. In this way, GSH helps prevent cells from premature aging. 

You can apply it in your products for its antioxidant function and aim for longevity and cellular health.

Antioxidant A
Liver Detoxification

L-Glutathione Reduced powder directly combines with heavy metals and other toxic metabolites through its active sulfhydryl (-SH) group. It can help detoxify the body without burdening the hepatic pathways. This reaction can efficiently convert harmful compounds into water-soluble substances for safe excretion.

If you are developing liver-support or anti-hangover products, we suggest applying high-purity GSH powder to promote the function of formulas. It can help protect liver cells from chemical damage and support liver metabolic functions.

Liver Detoxification
Mitochondrial Protection

L-Glutathione Reduced powder protects the mitochondrial membrane during ATP generation. It helps with cellular energy generation without increasing oxidative stress. This protection can efficiently reduce lactic acid accumulation and alleviate muscle fatigue after sports.

If you are willing to optimize your sports nutrition products or energy-boosting dietary supplements, GSH powder with high bioactivity is recommended. It helps maintain physical stamina and supports cellular recovery.

Mitochondrial Protection
Skin Brightening Antioxidant A Liver Detoxification Mitochondrial Protection

More About Our Company

  • Full experience in manufacturing L-Glutathione Reduced powder since 2017
  • Support global healthcare and skincare brands from over 50 countries
  • Advanced equipment and modern production lines ensure a stable supply chain for bulk orders
  • Compliance with global market regulatory requirements (like USP)
  • 10-20 g free sample for R&D testing and verification

Step 1: Raw Material Preparation and Dosing: We accurately weigh L-cysteine, L-glutamic acid, and glycine of high purity as the raw materials and thoroughly dissolve them.

Step 2: Enzymatic Reaction and Catalysis: We add Glutathione synthetase derived from natural organisms with ATP or ADP to initiate and accelerate the generation of Glutathione.

Step 3: Purification and Separation: The reaction solvent undergoes multi-stage filtration and chromatographic separation. In this stage, we precisely remove the unreacted amino acids, enzymes, and cofactors to ensure high molecular purity.

Step 4: Crystallization and Drying: The purified glutathione starts to crystallize under controlled temperature. The crystals are processed using low-temperature vacuum drying to yield high-purity L-Glutathione Reduced powder.

Step 5: Quality Testing and Packaging: We arrange multiple inspections, including assay, heavy metals, and microbiological indicators, to ensure uniform quality across batches. Then we seal the GSH powder into packaging to avoid exposure to air.

Water Soluble: Rapidly dissolves in water without precipitation or clumping while maintaining formulation texture. Ideal for clear liquid supplements, functional beverages, premium skincare lotions and serums. 

Exceptional Purity: Guaranteed purity up to 98%. Minimized heavy metals, sulfur odors, and unwanted impurities. Greatly reduces formulation risks and ensures stable quality of your final products across batches.

Outstanding Stability and Bioactivity: Strict quality control prevents degradation during production and storage. Stable bioactivity throughout the entire shelf life. Reduce batch variability and promote your final product efficacy.

Support Oral and Topical Use: Compliant with both pharmaceutical grade and cosmetic grade. You can apply it in both health care and skin care product lines. This simplifies sourcing and cuts management costs.

L-Glutathione Reduced COA
ItemSpecificationTest Method
AppearanceWhite crystalline powderVisual
Identification-IRCorresponding to reference spectrumUSP-NF2024 <197K>
Optical Rotation(1g/25ml)-15.5° to -17.5°USP-NF2024 <781S>
Assay(Dried)98.0% – 101.0%USP-NF2024
Purity≥ 98.0%USP-NF2024
Loss on drying≤ 0.5%USP-NF2024 <731>
Residue on ignition≤ 0.1%USP-NF2024 <281>
Bulk density0.4 – 0.5g/mLUSP-NF2024 <616>
Solvents residualEthanol: ≤ 5000ppmUSP-NF2024 <467>
Lead(Pb)≤ 0.1ppmICP-MS
Arsenic(As)≤ 2.0ppmICP-MS
Mercury(Hg)≤ 0.1ppmICP-MS
Cadmium(Cd)≤ 0.1ppmICP-MS
Iron≤ 10.0ppmUSP-NF2024 <241>
Chlorides≤ 200.0ppmUSP-NF2024 <221>
Sulphates≤ 300.0ppmUSP-NF2024 <221>
Ammonium≤ 200.0ppmUSP-NF2024
Related substancesTotal Impurity ≤ 2.0%USP-NF2024
Oxidized Glutathione ≤ 1.5%
Total Plate Count≤ 1000cfu/gUSP-NF2024 <61>
Yeast and Mold≤ 100cfu/gUSP-NF2024 <61>
Salmonella(CFU/10g)NegativeUSP-NF2024 <62>
Escherichia Coli(CFU/10g)NegativeUSP-NF2024 <61>
Staphylococcus  Aureus(CFU/10g)NegativeUSP-NF2024 <62>

Related Products

  • 3-O-Ethyl Ascorbic Acid A

    3-O-Ethyl Ascorbic Acid Powder can efficiently reduce oxidized glutathione to the active GSH form and maintain continuous antioxidant defense. L-Glutathione Reduced can precisely remove free radicals, limit the generation of melanin synthesis, and improve skin tone. 

    You can use them as a combo in your oral beauty formulations, aiming at consumers’ care for skin brightening and antiaging.

  • β-Nicotinamide Mononucleotide (NMN) powder A

    β-Nicotinamide Mononucleotide (NMN) can efficiently improve the NAD+ level in the cells for DNA repair and energy metabolism. L-Glutathione Reduced accurately targets oxidative stress and prevents mitochondrial damage caused by free radicals.

    You can combine them in your anti-aging formulas and target populations seeking cellular renewal and longevity.

  • Sodium Hyaluronate Powder A

    Sodium Hyaluronate efficiently locks in deep moisture in the cells to improve skin elasticity and hydration. At the same time, L-Glutathione Reduced handles hyperpigmentation and oxidative damage to restore the skin’s glow. 

    You can apply both of them in your skincare formulations for people who are seeking a comprehensive “brightening plus hydration” solution.

  • Pyridoxal-5'-Phosphate Powder (P5P) A
    Pyridoxal-5'-Phosphate (P5P) Powder

    Pyridoxal-5′-Phosphate (P5P) is a key coenzyme. It can directly promote the generation of endogenous GSH. L-Glutathione Reduced targets toxins in the human body. In this way, it coordinates with the liver detoxification pathways to metabolize toxins in the body.

    You can make these ingredients a golden combo and apply them in your metabolic support formulations. They are ideal for consumers who require liver protection and daily detox care.

What Is the Production Process of Your L-Glutathione Reduced? Is It Fermented or Chemically Synthesized?

Sunjoy uses an enzymatic synthesis method to produce L-Glutathione Reduced powder. It is neither a traditional fermented method nor a chemically synthesized method. Compared with these two traditional production methods, the enzymatic synthesis method has three major benefits: 

  • Rapid reaction speed with high sensitivity
  • Clear process for a reliable and well-controlled quality
  • Environmentally friendly and causes minimal pollution
What Is the Difference Between Reduced Glutathione (GSH) and Oxidized Glutathione (GSSG)? Which One Is Better?

If you are seeking raw ingredients for your health care or skin care products, L-Glutathione Reduced (GSH) Powder is the better choice.

GSH is a powerful antioxidant with direct bioavailability. It is a mainstream raw ingredient for supplements and beauty products. Oxidized Glutathione (GSSG) is mainly applied in specific formulas and clinical diagnostic reference.

Reduced Glutathione (GSH) vs Oxidized Glutathione (GSSG)
Sourcing AspectReduced Glutathione Powder (GSH)Oxidized Glutathione Powder (GSSG)
Market Demand and VolumeIndustry standard ingredient; >90% global B2B order shareNiche/specialized ingredient; limited to research and specific blends
Formulation ApplicationsOral supplements (capsules/tablets/powders); skin-brightening cosmetics; liver supportRandD laboratory reagents; in vitro diagnostics (IVD); stress assay kits
Marketing Claims SupportHigh-potency skin brightening; anti-aging and antioxidant; cellular detoxUnsuitable for standalone antioxidant marketing claims
Processing and StabilityRequires precise anti-oxidation/moisture control; high active potencyHighly stable against further oxidation; negligible biological activity
Client Sourcing ROIHigh market awareness; faster time-to-market; high sales volume and reordersHigh market education cost; limited formulation scope; lower order frequency
How Do You Solve the Odor and Stability Issues of Reduced Glutathione in Formulation?

Compared with the traditional fermented method, our production method has minimal sulfurous impurities and ultra-low heavy metal residues. This cuts down the odor auto-oxidation generated at the source.

Technical Solutions
ChallengeRaw Material Advantage (Enzymatic Powder)Industry-Standard Solution (Powder Level)Mechanism and Expected Result
Sulfurous OdorUltra-low free H2​S, zero yeast stenchCyclodextrin dry blendingPhysical cavity adsorption, reducing odor emission
High selectivity, no metabolic byproductsDilution with low-hygroscopic excipients (MCC/Maltodextrin)Reducing odor density per unit volume
InstabilityFree of heavy metals (Cu2+/Fe3+)Synergistic dry blend (Dry blending with Vitamin C)Vitamin C consumes oxygen, protecting GSH
High crystallinity, low solid-state degradationDouble aluminum foil bag + Nitrogen flushing + DesiccantOxygen and moisture barrier, preventing degradation
Caking and MoistureLow initial moisture, superior powder flowabilityPhysical anti-caking agents (Silicon dioxide (for dry dosage forms))Improving powder fluidity, preventing clumping
Uniform particle size, controlled surface areaMesh size optimization (Particle size distribution control)Reducing moisture contact area, enhancing stability
What Are the Side Effects of L-Glutathione Reduced? Is It Safe?

In most cases, L-Glutathione Reduced is well-tolerated and quite safe to take. Side effects rarely occur. However, for people who are allergic to L-Glutathione Reduced, there are certain allergic reactions. 

Common Allergic Reactions:

Rapid heartbeats, throat tightness, skin irritations and itchiness, skin rash, hives, nausea, stomach cramps, dizziness, and joint pain, etc.

Caution: 

If multiple allergic reactions appear, it can be anaphylaxis. The users must seek medical attention immediately or call emergency services. We highly recommend printing this information on the label of your final product to avoid risks. 

Can You Provide Complete Compliance Documentation for the Global Markets?

Yes. We provide the whole package of documents for global compliance. Below is a quick reference table for you to check. If you need more details, please contact our service team for further information.

Document and Compliance Checklist
CategoryKey DocumentationStandard / ScopePurpose
Product QualityCOA and Technical Data Sheet (TDS)USP / EP Pharmacopeia GradeValidates purity, potency, and physicochemical specifications
Regulatory SafetyFDA Facility Registration and REACH StatementUS FDA and EU Chemicals RegulationEnsures legal market access and chemical compliance in NA and EU
Material SafetySDS / MSDS and Non-GMO / BSE-TSE Free StatementsGHS and Global Health Safety ProtocolsConfirms non-hazardous handling and safety from biological risks
Quality ControlGMP / ISO 9001 / ISO 22000 CertificatesInternational QA and Food Safety ManagementGuarantees standardized batch-to-batch production and quality control
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Looking for L-Glutathione Reduced powder? Sunjoy supplies it stably and ensures on-time delivery with our advanced equipment and modern production lines. You are welcome to request a free 10-20g sample and full regulatory package. Contact us today to get your quotation soon.

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