Pure Thiamine Mononitrate
Direct Factory Supply Thiamine Mononitrate for Your Supplements and Nutritional Food
- CAS Number: 532-43-4
- EINECS Number: 208-537-4
- Molecular Weight: 327.36
- Molecular Formula: C12H17N5O4S
- Chemical Name: Thiamine Nitrate
- Related Name: Vitamin B1 Nitrate, Thiamine Mononitrate, Vitamin B1 Mononitrate, Aneurine Nitrate (old name)
- Appearance: White crystals or crystalline powder
What Is Thiamine Mononitrate?
Thiamine Mononitrate is a highly stable, low-hygroscopic form of Vitamin B1 used in dietary supplements. It provides a stable source of thiamine for nutritional applications. Thiamine Nitrate is a synthetic salt compound. It combines a thiamine cation with a functional nitrate anion.
When orally taken, Thiamine Nitrate is absorbed and converted into Thiamine Pyrophosphate (TPP). TPP is the vital coenzyme that drives the Krebs cycle to produce cellular energy (ATP). Therefore, Thiamine Nitrate can efficiently support metabolic processes and maintain the transmission of nerve system signals. It also helps maintain cardiac muscle health.
Thiamine Nitrate is widely applied in anti-fatigue supplements, premium Vitamin complex supplements, and metabolic support formulas.
Functions of Our Thiamine Mononitrate
Thiamine Nitrate is the key coenzyme in carbohydrate breakdown. It converts dietary glucose into usable ATP. It ensures efficient cellular respiration and prevents metabolic bottlenecks during high energy demand.
You can apply it in your energy beverages, Vitamin B complex supplements, and dietary supplements and highlight the function of promoting metabolic efficiency.
Thiamine Nitrate is essential for synthesizing acetylcholine. Acetylcholine is the key neurotransmitter that participates in memory, mood, and muscle control. It protects the nerve cells from degradation and helps maintain normal signal transmission.
You can apply it to your brain health formulations, stress-relief supplements, and cognitive support products.
Thiamine Nitrate plays a great role in the process of myocardial energy generation. It supports healthy heart muscle contractions and helps maintain healthy cardiovascular function and fluid balance in the cardiac tissue.
We suggest applying it in your cardiovascular health capsules, adult wellness formulas, and heart support supplement products.
Thiamine Nitrate can help with the secretion of hydrochloric acid in the stomach for food digestion and nutrient absorption. It helps maintain a healthy tone of the stomach and gut, and helps maintain a good appetite.
We recommend using it in your digestion health tablets, appetite booster syrup, and comprehensive nutrition powders.
More About Our Company
- Professional Thiamine Mononitrate Supplier
- Features
- Production
- Specification
- Experienced in producing Thiamine Nitrate powder since 2017
- Free sample of 10-20 g for lab testing and verification
- Partner with overseas brands from over 50 countries
- Strict quality assurance compliant with USP and EP
- Flexible MOQ, starting from just 1 kg
Superior Purity: 98.0-102.0% purity meets USP, EP, and BP standards. Strictly controlled heavy metals and solvent residues. The superior purity ensures the safety and consistency of your final products.
Excellent Stability and Low Hygroscopicity: Lower hygroscopicity and higher stability compared to Thiamine HCI. Optimal performance under conditions of moisture, lighting, and production. Extends the shelf life of your final products effectively.
Outstanding Flowability: Excellent free-flowing property and uniform dispersibility prevent caking and dust generation. Perfectly adapt to dry blending, tableting, and capsule filling. Promote production efficiency significantly and reduce material loss.
Reliable Bulk Supply: Sunjoy is a direct manufacturer with large-scale annual capacity and ready stock. We ensure competitive factory prices and superior quality consistency across batches. Your ingredient powder will be delivered on schedule.
Step 1: Formylation Reaction: We use Aminopropionitrile as the core ingredient, apply Methyl formate as the formylation agent, and use Sodium methoxide as a catalyst to process the formylation reaction.
Step 2: Primary Separation and Drying: After the formylation reaction, the mixture undergoes an isolation process to yield the primary intermediate. Then they are processed with a drying step to remove moisture and residual solvents.
Step 3: First Cyclization Reaction: The dried intermediate is processed in the first cyclization reaction with o-chloroaniline and hydrochloric acid (HCl). In this step, it forms the heterocyclic intermediate core.
Step 4: Separation, Washing and Drying: The cyclized product is separated and washed to eliminate unreacted residue and byproducts. Then it undergoes a drying process to prepare for the subsequent condensation stage.
Step 5: Second Cyclization Reaction: We mix the dried intermediate with Acetamidine hydrochloride and Sodium methoxide to process the second cyclization reaction. In this stage, the essential pyrimidine ring of the Thiamine structure is formed.
Step 6: Hydrolysis Reaction and Final Purification: The final intermediate undergoes the Hydrolysis reaction with hydroxide (NaOH) and methanol, and finally yields high-purity Thiamine Nitrate (Vitamin B1).
| Process Parameters and Raw Materials | ||||
| Process Stage | Phase Name | Raw Materials and Reagents Added | Core Chemical / Operations | Key Objective and Function |
| Stage 1 | Formylation | Aminopropionitrile, Methyl formate, Sodium methoxide | Formylation reaction | Attach the formyl group to start the synthesis chain |
| Stage 2 | Intermediate 1 Prep | / | Separation and Drying | Isolate and purify intermediate powder; remove solvents |
| Stage 3 | First Cyclization | O-chloraniline, Hydrochloric acid (HCl) | Cyclization reaction | Form the preliminary ring structure |
| Stage 4 | Intermediate 2 Prep | / | Separate, Wash and Drying | Remove by-products and unreacted reagents |
| Stage 5 | Second Cyclization | Acetamidine hydrochloride, Sodium methoxide | Cyclization reaction | Build the pyrimidine structure of Thiamine |
| Stage 6 | Hydrolysis and Finishing | Sodium hydroxide (NaOH), Methanol | Hydrolysis reaction | Final cleavage and salt/base formation for pure Thiamine Nitrate |
| Thiamine Mononitrate COA | |
| Items of analysis | Specification |
| Appearance | White or almost white, crystalline powder |
| Identification | Must comply with the identification tests A, B, C, D of USP2025 |
| Chloride and Sulfate, Chloride | Not more than 0.06% |
| Related Compounds | Not more than 1.0% |
| pH | 6.0 to 7.5 |
| Loss on drying | Not more than 1.0% |
| Residue on ignition | Not more than 0.2% |
| Assay | 98.0%~102.0% |
| Total aerobic count | ≤1000cfu/g |
| Molds and yeasts | ≤100cfu/g |
Related Products
Pyridoxamine DihydrochloridePyridoxamine Dihydrochloride can actively capture reactive carbonyl species to prevent the generation of Advanced Glycation End-products (AGEs). While Thiamine Nitrate drives smooth glucose metabolism for cellular energy generation. When they work together, they can help support healthy metabolic function and shield against diet-related metabolic stress.
We suggest you combine both of them in your anti-glycation and metabolic health formulas as a golden duo. They are ideal for people who require daily blood sugar management and anti-aging protection.
Pyridoxal-5'-Phosphate Powder (P5P)Pyridoxal-5′-Phosphate (P5P) can directly accelerate amino acid metabolism and neurotransmitter synthesis without conversion by the liver. Thiamine Nitrate can initiate carbohydrate breakdown for the energy cycle. In this way, they enhance the resilience of the nervous system and optimize energy generation.
You can apply both of these ingredients to your premium Vitamin B complex formulations and cognitive support supplements. They are very suitable for populations who seek rapid energy recovery and nervous system support.
Riboflavin (Vitamin B2) provides precursor molecules for FAD and FMN to maintain mitochondrial electron transport. Thiamine Nitrate offers the necessary coenzyme for glucose catabolism. They work together to form a consistent energy pathway to relieve body fatigue.
You can combine them in your energy recovery supplements and anti-fatigue formulations, and aim at people who require long-lasting vitality.
β-Nicotinamide Mononucleotide Powder (β-NMN) can improve the cellular NAD+ level. It accelerates ATP generation and cellular recovery. Thiamine Nitrate optimizes the process of pyruvate entering the Krebs cycle for initial energy release.
You can apply them in your longevity-focused and cellular vitality formulas targeting consumers who require comprehensive mitochondrial health and vitality restoration.
Both Thiamine Nitrate and Thiamine Hydrochloride provide the active form of Vitamin B1. But Thiamine Nitrate has significantly higher stability in dry conditions compared to Thiamine Hydrochloride. The non-hygroscopic nature makes Thiamine Nitrate optimal for dry oral dosage forms and food fortification.
Here is a comparison table for quick reference. If you feel confused about the selection between them, feel free to contact our service team for specific advice.
| Thiamine Mononitrate vs Thiamine Hydrochloride | ||
| Key Parameters | Thiamine Nitrate (Mononitrate) | Thiamine Hydrochloride (HCl) |
| Hygroscopicity | Very Low (Non-hygroscopic) | High (Absorbs moisture easily) |
| Stability in Dry Forms | Outstanding stability | Less stable in humid environments |
| Solubility | Sparingly soluble in water | Freely soluble in water |
| Primary Applications | Tablets, Capsules, Food Fortification | Liquids, Injections, Premixes |
Our Thiamine Nitrate powder is strictly compliant with USP, EP, FCC, and CP standards. We operate under strict GMP regulations and have comprehensive international certifications, such as ISO9001 and FSSC22000.
We provide comprehensive COA, SDS, and stability test data along with every batch of our product.
To maintain the maximum potency and prevent variation in physical properties, Thiamine Nitrate powder should be stored in a cool, dry, and well-ventilated condition.
The powder should be kept from direct exposure to light (especially UV light), moisture, and high-temperature sources. We recommend storing it in an environment below 25°C and keeping the packaging tightly closed when not in use.
Under proper storage conditions, the shelf life is over 24 months.
For bulk orders over 25kg, we use fiber drums with food-grade PE bags inside to protect the powder during long-distance international transit. The solid package prevents moisture exposure and physical damage.
As a direct manufacturer, we have massive annual capacity to support stable long-term orders. We provide a flexible MOQ and free samples of 10-20 g. You can have primary lab tests before placing bulk orders.
Yes. Thiamine Nitrate has excellent formulation compatibility.
Due to its stable chemical structure and non-hygroscopic property, when it is mixed with other ingredients, the risk of cross-reactions is minimized. Even when formulated with aggressive components like Vitamin C, Iron, or Copper in multivitamin blends, it shows superior stability.
Its excellent flowability also makes it free of caking issues and ideal for products such as direct compression in complex tablet and hard capsule formulations.
The reference table below lists common paired ingredients and the final products.
| Common Combinations and End-Consumer Products | |
| Paired Ingredients | Typical End-Consumer Products (B2C) |
| Vitamin B Complex (B2, B3, B6, B12) | B-Complex Energy Tablets, Anti-fatigue Capsules, Stress-relief Gummies |
| Vitamin C & Zinc | Immune Support Supplements, Daily Multivitamin Tablets |
| Iron & Folic Acid | Women’s Health Supplements, Prenatal Vitamins, Blood Health Formulas |
| Taurine & Caffeine | Energy Drinks, Pre-workout Powders, Functional Shots |
| Magnesium & Calcium | Bone and Muscle Health Tablets, Sports Recovery Supplements |
| Ginseng & Maca Extract | Herbal Energy Boosters, Men’s Vitality Capsules |
Compared with other Thiamine salts, Thiamine Nitrate has superior dry-heat resistance. In general, all forms of Vitamin B1 are sensitive to extreme heat and alkaline environments. Our Thiamine Nitrate powder has a high retention rate during processes such as baking, pasteurization, and extrusion.
This property makes it ideal for nutrition enhancement of baked functional foods, breakfast cereals, and extruded pet kibble.
To maximize the retention rate of Vitamin B1, we suggest applying Thiamine Nitrate powder during the later stages of processing, or controlling the temperature and pH environment of the processes.
Contact Us
If you need a stable supply of bulk Thiamine Mononitrate powder, Sunjoy perfectly meets your demands. With our large-scale capacity, we guarantee on-time delivery for your orders. Contact us today and get your free sample.
