Riboflavin-5-Phosphate Sodium Wholesale Manufacturer
Sunjoy provides high-purity riboflavin-5-phosphate sodium API for your formulation needs.
- CAS number: 130-40-5; molecular formula: C17H20N4NaO9P; molecular weight: 478.33; EINECS number: 204-988-6
- Synonyms: flavin mononucleotide sodium salt, FMN sodium salt, vitamin B2 phosphate, and E101a
- Solubility: freely soluble in water, slightly soluble in alcohol, and practically insoluble in other solvents
- Appearance: Yellow or orange-yellow crystalline powder
- Packaging: 1 kg aluminum foil bags, 25 kg fiber drums with inner double-layer PE bags
What Is Riboflavin-5-Phosphate Sodium?
Riboflavin-5-phosphate sodium, which naturally occurs in some dairy products, is the sodium salt of the phosphorylated form of vitamin B2 (riboflavin). Compared with riboflavin, riboflavin-5-phosphate sodium exhibits superior water solubility, enabling its flexible application in formulation development.
Riboflavin-5-phosphate sodium is the essential source of vitamin B2 for the human body. Thus, it can be used in vitamin supplements. For its orange color, it is also known as E101a as a natural food colorant. So far, it has been widely used in dietary supplements, functional foods, beverages, and pharmaceuticals.
Applications of Sunjoy Riboflavin-5-Phosphate Sodium
Riboflavin-5-phosphate sodium is the phosphorylated form of vitamin B2 and can be used as a stable source of vitamin B2 in various dietary supplements. The superior water solubility makes it ideal for various product forms. You can process it into multivitamin B products, vitamin B capsules, tablets, and powders.
Besides serving as a source of vitamin B2, vitamin B2 phosphate, or E101a, is also used as a natural food colorant in foods and drinks. You can use our food-grade riboflavin-5-phosphate sodium in functional foods, beverages, and infant and toddler nutrition products. You can also use E101a in candies, baked products, and dairy desserts.
Sunjoy pharmaceutical-grade riboflavin-5-phosphate sodium can serve as an active vitamin B2 API ingredient in pharmaceutical and health products. It is used in oral vitamin supplements, injectable vitamin formulations, and certain ophthalmic formulations, such as riboflavin ophthalmic drops.
Considering that vitamin B2 participates in energy metabolism, Sunjoy riboflavin-5-phosphate sodium can be used in sports nutrition to offer vitamin support. You can use our ingredients in sports nutrition powders and some sports functional formulations.
Our riboflavin-5-phosphate sodium can also be used as a vitamin B2 source for veterinary vitamin products, pet nutritional supplements, feed premixes, and nutritional formulations for poultry and livestock. The stable nutrition content and advanced formulation compatibility enable our ingredients to meet the veterinary requirements.
In biochemical research and formulation development, riboflavin-5-phosphate sodium has certain application values. Our ingredients can be used in research on flavin coenzymes, enzyme activity, and cellular metabolism.
More About Our Company
- Professional Riboflavin-5-Phosphate Sodium Supplier
- Features
- Synthesis Procedures
- Certificate of Analysis
- 10+ years of experience in manufacturing riboflavin-5-phosphate sodium
- Transparent and traceable production chains for bulk orders
- Complies with USP and BP standards
- Customizable packaging and ingredient specifications
Standardized High Assay: Riboflavin-5-phosphate sodium features stable active content. With an assay of ≥73.0%, our API ingredients meet food-grade and pharmaceutical-grade standards.
Excellent Water Solubility: After phosphorylation treatment, our riboflavin-5-phosphate sodium features superior water solubility, adapting well to different dosage forms.
Consistent Riboflavin-5-Phosphate Sodium Content: Through standardized manufacturing and strict quality control, we ensure every batch of vitamin B2 phosphate remains stable and consistent.
High Bioavailability of Vitamin B2: As the phosphorylated form of vitamin B2, our ingredient provides a readily available form of riboflavin for commercial applications.
Global Compliance: Our ingredients comply with USP and BP standards. You don’t have to worry about cargo entry into your target markets.
Comprehensive Quality Testing: We conduct multiple tests, including HPLC assay, moisture, residues, and other specifications. The testing system provides quality credibility for our products.
Documentation Support: We provide a comprehensive set of quality documentation. COAs, MSDS, certificates of origin, third-party inspections, and other documents are available.
Stable Production Capacity: With well-established manufacturing lines compliant with ISO and GMP standards, we offer quality-assured riboflavin-5-phosphate sodium for your bulk orders.
Riboflavin Phosphorylation: Riboflavin is the raw material for riboflavin-5-phosphate. During this stage, we carefully select high-purity riboflavin and convert it into riboflavin-5-phosphate through phosphorylation.
During phosphorylation, we carefully control the temperature, time, reagent ratios, and pH conditions. Thus, we improve conversion efficiency and reduce unreacted riboflavin.
Hydrolysis Reactions: After phosphorylation, there may be some unconverted materials and side products. Hydrolysis reactions can hydrolyze by-products and remove unstable impurities. By doing so, we ensure the purity of the final product.
Filtration and Purification: Common technologies include filtration, absorption purification, concentration, and other measures. These steps can further remove unreacted ingredients and residues. Thus, we control the assay, color, and quality consistency of your riboflavin-5-phosphate.
Neutralization and Sodium Salt Formation: Purified riboflavin-5-phosphate needs to be converted into a solid salt form. We add alkaline sodium into solvents. Then riboflavin-5-phosphate becomes riboflavin-5-phosphate sodium. The salt forms can improve the water solubility and formulation compatibility of our product.
Dissolution and Refinement: The crude riboflavin-5-phosphate sodium needs dissolution and refinement to improve the product purity and uniformity. Stages include water dissolution, precision filtration, recrystallization, concentration adjustment, and other procedures. Through dissolution and refinement, our product has superior quality.
According to your needs, we can customize our riboflavin-5-phosphate to meet various standards. Whether for food, nutritional, or pharmaceutical-grade standards, our ingredients are qualified and compliant.
Drying and Quality Inspections: We dry the refined wet powder to remove moisture. Generally, we use vacuum drying to evaporate excessive water at a lower temperature.
After drying, riboflavin-5-phosphate undergoes our comprehensive test system. Tested specifications include HPLC assay, moisture content, residual solvents, heavy metals, microbials, and other parameters, ensuring it meets USP and BP regulations.
| Item | Specifications | |
| Assay (on dried basis) | 73.0-79.0% | |
| Standard | USP/BP | |
| Appearance | Yellow or orange-yellow crystalline, hygroscopic powder | |
| Identification | Positive | |
| Loss on Drying | ≤7.5% | |
| Specific optical rotation | +37.0-+42.0° | |
| Lumiflavin | A440nm≤0.025 | |
| Free Riboflavin | ≤6.0% | |
| Riboflavin Diphosphates | ≤6.0% | |
| Free Phosphate | ≤1.0% | |
| Residue on ignition | ≤25.0% | |
| Inorganic phosphate | ≤1.5% | |
| pH | 5.0-6.5 | |
| Organic volatile impurities | Meets the requirements | |
| Heavy Metals | ≤10ppm | |
| Microbial limit | Aerobic bacteria | ≤1000 CFU/g |
| Mould & Yeast | ≤100 CFU/g | |
| Shelf life | 24 months if appropriately stored | |
| Storage | Store at room temperature (18-25℃) and away from moisture. | |
| MOQ | Flexible MOQ starting at 100g | |
| Samples | 10g-20g free samples available, and the shipping costs will be covered by the clients. | |
| Dispatch Time | Within 5-7 business days after your payment | |
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| Differences | Riboflavin-5-Phosphate | Riboflavin |
| Chemical Form | The sodium phosphate form of riboflavin, a water-soluble vitamin B2 derivative | Standard riboflavin (vitamin B2) |
| Water Solubility | Superior water solubility, more suitable for liquid formulations and water-based systems | Relatively low water solubility, has certain limitations in liquid formulations |
| Formulation Compatibility | Products with high solubility requirements, such as functional beverages, liquid nutritional supplements, and multivitamins | More commonly used in traditional solid dosage forms, like tablets and capsules |
| Application | Dietary supplements, food and beverages, pharmaceutical formulations, and fortified products | Dietary supplements, food fortification, and vitamin products |
| Processing Advantage | Improved solubility for better flexibility in formulation development | Formulations need optimization for solubility |
| Price | Higher | More cost-effective |
Riboflavin-5-phosphate sodium and riboflavin can all be used as sources for vitamin B2. Considering their differences in water solubility, they are suitable for different dosage forms.
If you plan to develop liquid products or formulations requiring high water solubility, riboflavin-5-phosphate is an ideal choice. Riboflavin exhibits superior solid stability, more suitable for standard vitamin B2 supplements.
We offer riboflavin-5-phosphate sodium that meets USP (United States Pharmacopeia) and BP (British Pharmacopoeia) standards. In addition to pharmacopoeial grades, our API ingredients also meet FSSC food grades. Our riboflavin-5-phosphate sodium has a wide range of applications, ideal for your flexible formulation designs.
These benefits and functions are only for your reference, not medical advice. For more detailed information, please consult professionals.
Vitamin B2 Nutritional Source
Riboflavin-5-phosphate sodium can be used as a vitamin B2 ingredient in supplements. Compared with regular riboflavin, the phosphorylated form has better water solubility, making it more suitable for nutritional product formulations.
Support Normal Energy Metabolism
Vitamin B2 plays a role in the formation of flavin coenzymes, such as FMN and FAD. Flavin coenzymes are involved in the metabolism of carbohydrates, fats, and proteins. Therefore, riboflavin-5-phosphate sodium can be used to support energy metabolism.
Support Tissue Maintenance
Riboflavin-5-phosphate sodium can provide vitamin B2 to the human body. This ingredient is helpful for cellular metabolism, helping maintain the normal functions of tissues such as skin, oral mucosa, and eye tissues.
What Are the Side Effects of Riboflavin-5-Phosphate Sodium?
These side effects are for reference only and not medical claims. For detailed advice, you can consult the professionals. Riboflavin-5-phosphate sodium is commonly seen as safe. At the recommended dosage, it is less likely to cause significant side effects. However, some mild reactions need your attention.
Yellow Urine Color
Riboflavin-5-phosphate sodium has a natural yellow color. When people take in products containing this ingredient, some unabsorbed components may be excreted from the body through urine. In this process, riboflavin-5-phosphate sodium may turn the urine yellow. It is common and natural, and people need not worry about it.
Mild Digestive Discomfort
If formulations contain a higher amount of riboflavin-5-phosphate than the recommended dosage, some people may experience mild side effects. Common discomforts include stomach discomfort, nausea, and bloating. In your formulation development, it is recommended to carefully design the active ingredient content.
Allergic Reactions
Some sensitive people may be allergic to riboflavin-5-phosphate and products containing this ingredient. Some mild allergic reactions may happen, including skin sensitivity and gut discomfort. These side effects are commonly temporary.
Contact Us
Don’t know where to buy riboflavin-5-phosphate in bulk? Sunjoy is your best choice! We provide you with premium ingredients with flexible MOQ. Whether for formulation development or commercial manufacturing, we are your good procurement partner. Contact us and get free samples!
