Bulk Pyrroloquinoline Quinone Powder
Pure PQQ Powder for Your Healthcare Products
- CAS Number: 122628-50-6
- EINECS Number: 200-001-8
- Molecular Weight: 374.17
- Molecular Formula: C14H4N2Na2O8
- Chemical Name: Pyrroloquinoline Quinone
- Related Name: PQQ, PQQ Powder, Methoxatin (old name), Disodium PQQ, PQQ Disodium Salt, Pyrroloquinoline Quinone Disodium Salt, Coenzyme PQQ, Pyrroloquinoline quinone disodium salt
- Appearance: Red to reddish-brown powder
What Is Pyrroloquinoline Quinone Powder?
Pyrroloquinoline Quinone (PQQ) is an advanced ingredient widely applied in various dietary supplements. It directly interacts with cellular components and stimulates the generation of new mitochondria within cells. Mitochondria produce cellular energy and maintain metabolic efficiency.
Therefore, PQQ can efficiently support daily energy of the human body, promote mind clarity and focus, and protect cells from oxidative damage. Additionally, it helps with nervous system and cardiovascular health in the long term.
PQQ powder is commonly used in cellular health supplements, premium cognitive formulas, and premium longevity and anti-aging products.
Functions of Our Pyrroloquinoline Quinone Powder
PQQ powder actively stimulates the production of mitochondria and supports comprehensive cellular energy metabolism. It promotes the efficiency of ATP production and provides continuous energy without increasing additional burden to the body. This mechanism makes it optimal for maintaining vitality and resisting daily fatigue.
You can utilize our PQQ powder in your healthcare products such as energy-enhancing supplements and physical vitality formulations.
As a dietary antioxidant, PQQ actively removes free radicals in the human body. It effectively protects essential biological macromolecules from the damage of daily oxidative stress. By removing free radicals, it maintains the integrity of cellular structures and supports physical health in the long term.
You can apply our PQQ powder in your products such as daily nutritional supplements, cellular health products, and facial anti-aging formulations.
PQQ helps support normal neurological function of the nervous system and overall brain health. It assists in daily concentration and alertness by keeping nerve pathways well nourished. This makes it ideal for people who handle intensive mental work.
You can apply PQQ powder in your cognitive product line and make it into cognitive support capsules, brain health formulations, and general dietary supplements.
PQQ powder supports healthy blood circulation and promotes daily nutritional status. It helps maintain oxidative balance within the circulatory system and ensures the transfer of nutrients. This feature makes it ideal for comprehensive heart formulations.
You can apply PQQ powder in your heart health formulations and comprehensive daily dietary supplements.
More About Our Company
- Professional Pyrroloquinoline Quinone Powder Supplier
- Features
- Specification
- Served global healthcare brands across 50 countries
- Over 10 years of experience in manufacturing Pyrroloquinoline Quinone powder
- 10g to 20g free sample available for lab testing
- Flexible MOQ starts from 100g, extra discount for bulk orders over 10kg
- Reliable supply capacity for bulk orders in the long term
Superior Purity: Superior purity of 98.0% – 102.0% (HPLC tested) for your high-end products. Strictly controlled heavy metals, bacteria, and solvent residues. Ensures high safety of your final products.
Outstanding Stability: Resilient to heat and light exposure during standard manufacturing processes. Wide tolerance range of pH conditions. Stable in blending formulations such as vitamin complex.
Consistent Across Batches: Strict quality control with multiple inspections during production. Consistent status of PQQ powder from batch to batch ensures uniform quality of your final products.
Competitive Direct Factory Pricing: As a direct manufacturer, Sunjoy offers competitive pricing by eliminating intermediary loss. Our annual production of PQQ powder reaches 10 tons. With our large-scale production capacity, we guarantee on-time delivery to meet the lead time.
| Pyrroloquinoline Quinone Powder COA | ||
| TEST ITEM | METHOD | STANDARDS REQUIRED |
| Appearance | Visual | Reddish-brown powder |
| Identification | HPLC | The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay |
| Particle Size | USP <786> | Not less than 99% through 80 mesh |
| Water Determination | USP ⟨921⟩ | NMT 13.0% |
| Assay | HPLC | 98.0%-102.0% |
| Cadmium | AAS | ⩽0.5ppm |
| Lead | AAS | ⩽0.5ppm |
| Arsenic | AAS | ⩽1.0ppm |
| Mercury | AAS | ⩽0.1ppm |
| Total Aerobic Microbial Count | USP <2021> | ⩽1000CFU/g |
| Yeasts and Molds | USP <2021> | ⩽100CFU/g |
| E.coli | USP <2022> | Negative/10g |
| Salmonella | USP <2022> | Negative/10g |
| Staphylococcus aureus | USP <2022> | Negative/10g |
| MOQs | 100g/ Bag | |
| Sample | Available (10-20g/ bag) | |
Related Products
Coenzyme Q10 effectively provides cellular energy and optimizes the energy production of vital organs. PQQ stimulates the biogenesis of new mitochondria and protects existing ones from oxidative damage.
We recommend you combine them in your health care products and highlight the functions of cellular energy and mitochondrial health in your product promotions.
NMN can efficiently promote NAD+ levels. It helps with the recovery of cellular energy and DNA repair. PQQ helps promote cellular rejuvenation and supports nervous system wellness by stimulating nerve growth factors.
We recommend applying both of them in your premium longevity products and targeting senior populations.
Urolithin A PowderUrolithin A powder removes damaged mitochondria and supports mitochondrial health by promoting mitophagy. PQQ powder helps enhance mitochondrial functions and protect cells from oxidative damage.
We recommend combining these two ingredients in your premium anti-aging products with their functions of comprehensive mitochondrial renewal and cellular anti-aging.
L- Glutathione Reduced is a powerful antioxidant. It neutralizes free radicals and supports cellular detoxification. PQQ powder supports cellular energy and defends against oxidative stress at the microscopic level.
You can apply them in your dietary supplements and highlight the functions of cellular defense and antioxidant support of the whole body.
Step 1: Coupling Reaction Phase
We apply 6-Amino-5-methoxy-1H-indole-2-carboxylic acid ethyl ester and Dimethyl 2-oxopentanedioate as the raw materials for the ring-formation reaction.
Step 2: Dehydration Cyclization and Oxidation Reaction
We build the core ring system through a dehydration cyclization step. Then we introduce an oxidative reaction to form the key functional group structure.
Step 3: Hydrolysis Conversion
The intermediate is thoroughly dissolved and filtered to remove residues. Then it undergoes a hydrolysis reaction. In this stage, the ester groups are smoothly converted into acid structures. After the hydrolysis reaction, the mixed solution undergoes a second filtration procedure.
Step 4: Crystallization in the Clean Area
The mixed solution is transferred into the clean area for the crystallization process. The solution precipitates high-purity target product.
Step 5: Centrifugation, Drying, Crushing and Sieving
We separate the crystals with centrifugation and show drying under Critical Control Point 1 (CCP1). Then the product is crushed and sieved under the monitoring of Operational Prerequisite Program 1 (OPRP1).
Step 6: Packaging and Metal Inspection
We seal the PQQ powder with food-grade PE bags. After being processed by metal detection (Metal detection) at Critical Control Point 2 (CCP2), the powder is packed with aluminum foil bags or cardboard drums.
| PQQ Manufacturing Process and Operational Parameters | |||
| Steps | Process / Operation Name | Main Operations and Equipment | Quality Control and Clean Requirements |
| Stage 1 | Coupling and Ring Formation | React 6-amino-5-methoxy-1H-indole-2-carboxylic acid ethyl ester with dimethyl 2-oxopentanedioate | Standard reaction control |
| Stage 2 | Dehydration and Oxidation | Shows dehydration cyclization to build the core structure, followed by oxidation | Reaction endpoint monitoring |
| stage 3 | Dissolution, Filtration, and Hydrolysis | Dissolve, filter impurities, and show hydrolysis to convert functional groups | Purity and conversion rate control |
| Stage 4 | Pre-filtration and Crystallization | Filter and enter the Clean area for crystallization | Clean area environment |
| Stage 5 | Centrifugation, Dry, Crush and Sieve | Centrifugal separation, CCP1 drying, crushing/sieving with OPRP1 | CCP1 / OPRP1 |
| Stage 6 | Packaging and Metal Detection | Polyethylene bag inner pack, CCP2 metal detection, aluminum foil bag and cardboard drums outer pack | CCP2 / Food-grade packaging |
PQQ powder should be tightly sealed each time after use. It should be stored in cool, dry places and should avoid direct light or heat in long-term storage. Under proper storage conditions, the shelf life is over 24 months.
No. PQQ and CoQ10 are not the same substances. But they partner in a synergistic manner in cellular energy metabolism.
CoQ10 mainly exists in the inner mitochondrial membrane. It directly participates in ATP generation.
PQQ supports mitochondrial functions and stimulates mitochondrial production. It also facilitates more powerful antioxidative capacity.
These two ingredients are commonly combined as a golden duo in premium anti-aging products and mitochondrial health formulas for more comprehensive effects of cellular protection and energy promotion.
Here is a comparison table of CoQ10 and PQQ for quick reference.
| CoQ10 vs PQQ | ||
| Feature | Pyrroloquinoline Quinone (PQQ) | Coenzyme Q10 (CoQ10) |
| Primary Function | Promotes mitochondrial biogenesis & antioxidant | Involved in electron transport & ATP production |
| Antioxidant Potency | Extremely high (catalytic antioxidant properties) | High (traditional lipid-soluble antioxidant) |
| Synergy | Works synergistically when paired with CoQ10 | Often paired with PQQ for comprehensive cellular energy |
PQQ powder shows moderate sensitivity to light, elevated temperatures, and humidity. Continuous exposure to strong lighting conditions or high-humidity environments can lead to degradation and potency loss.
During the manufacturing process, the conditions of lighting, moisture, and heat should be controlled.
PQQ shows excellent stability in final products that apply proper technological measures such as microencapsulation. It maintains outstanding purity and bioactivity during shelf life.
The standard recommended dosage of PQQ powder is determined by the local regulatory requirements and the product positioning.
In general, the daily intake of dietary supplements, such as capsules and tablets, ranges from 10mg to 20mg.
As for functional food and beverages, it depends on the specific application. The common dosage ranges from 5 mg to 10 mg per serving. The specific dosage should be adjusted based on local regulations and product formulation requirements.
PQQ is well compatible with various active ingredients such as Vitamin C in formulations. As a powerful antioxidant, our PQQ powder pairs complementarily with Vitamin C. But in complex multi-mineral formulas, free metal ions may catalyze oxidative reactions on sensitive compounds.
Therefore, when developing complex dry-blend or liquid formulations, we suggest utilizing proper technical measures (or techniques), such as encapsulation, antioxidant synergy, or moisture control, for long-term stability of your final products.
The table below showcases common complex formulations of PQQ. If you need more information, feel free to contact our service team for further guidance and your tailored solution.
| Common PQQ Combination Product Application | ||
| Combination Product Type | Core Ingredient Combination | Stable Formulation and Processing Information |
| Mitochondrial and Energy Premix | PQQ + CoQ10 + B Vitamins | Standard dry-blending, suitable for capsules and tablets |
| Antioxidant Complex Powder | PQQ + Vitamin C + Zinc | Strong antioxidant synergy, controlled water activity processing |
| Multi-Vitamin and Mineral Premix | PQQ + PS + Mineral Complex | Addressing free metal ions, utilizing encapsulation or antioxidant synergy |
| Advanced Nutrient Formulation | PQQ + Vitamin K2 + D3 + Calcium/Magnesium | Favorable pH tolerance and compatibility, suitable for solid or liquid dosage forms |
Sunjoy produces PQQ powder following the strict manufacturing and safety standards for global market compliance. Our production system meets GMP, ISO 22000, and HACCP standards for quality and safety management.
Contact Us
Sunjoy manufactures pure PQQ powder with high stability and consistency across batches. If you are looking for bulk PQQ powder, contact us and get your free sample today.
