High-Assay Berberine: We ensure a reliable berberine assay of 97%+, ideal for your premium and long-term product development.

Standardized Berberine Content: Through strict manufacturing control and HPLC testing, we precisely monitor berberine hydrochloride production, preserving berberine quality consistency.

Traceable Botanical Source: We establish a comprehensive material traceability system to track and manage the sourcing, procurement, and processing of our raw materials.

Advanced Extraction Procedure: We use botanical extraction, resin adsorption, vacuum concentration, and other optimized extraction processes to achieve consistent berberine content and reliable product quality.

Strict Testing System: We establish a comprehensive testing system covering HPLC assay, heavy metals, and other parameters, ensuring our berberine HCl powder meets market requirements.

Reliable Bulk Supply: With mature manufacturing procedures and stable supply chain management, we can continuously produce berberine hydrochloride powder for your procurement.

Documentation Support: We provide comprehensive quality and compliance documentation for global logistics and market regulatory standards.

Flexible MOQ: We provide MOQ down to 100 g. Flexible MOQ services meet your different requirements for your formulation development and commercial manufacturing.

Raw Material Processing: Commonly, we use Phellodendron chinensis or Coptis chinensis as our raw materials. First, we conduct quality selection of raw materials, including specifications such as appearance, moisture content, purity evaluation, and contaminant screening.

To ensure our materials have stable berberine content, we wash, dry, and grind the materials. By controlling the size of pieces, we increase the contact area between berberine and the solvent, thereby improving the extraction efficiency.

Berberine Extraction: Common extraction methods include water, ethanol, and hydroalcoholic extraction. During the extraction procedure, we control the solvent ratio, extraction temperature, extraction time, and pH. Then, the berberine in plants can be further released into solvents. Now we get the solution containing berberine.

Filtration and Separation: Besides berberine, the solution also contains plant fibers, proteins, polysaccharides, and other untargeted components. We use filtration, centrifugation, and even membrane separation to remove unwanted impurities.

Concentration and Purification: We use vacuum concentration to evaporate excessive liquid at a lower temperature. Then, berberine is less affected by heat. In the purification stage, we use resin adsorption to absorb berberine. Then we conduct column and solvent purification to remove pigments, unnecessary alkaloids, and plant impurities.

Salt Formation and Crystallization: After purification, hydrochloric acid is added to convert berberine into berberine hydrochloride. The salt formation process promotes crystallization through solubility differences. Then, berberine hydrochloride crystals precipitate from the solution. 

This integrated salt formation and crystallization process helps get a standardized berberine HCl powder with consistent quality.

Crystallization and Drying: By controlling the solvent temperature, concentration, and other specifications, we can crystallize the berberine hydrochloride. This stage can further improve the product purity. Then, we use vacuum drying to remove moisture. After that, we get the yellow crystalline powder.

Particle Size Control: We conduct milling and sieving to control the particle size, and the particle size is customizable. The small-particle berberine HCl powder exhibits advanced flowability and form compatibility. You can manufacture our product into capsules, tablets, and other forms.

Quality Testing: Before packaging and shipping, quality inspection is important. We have established a comprehensive inspection system. Specifications such as HPLC assay, appearance, impurities, and others are tested to ensure qualification.

Our tests are traceable. Third-party inspections are also provided. You don’t have to worry about the product credibility and safety. We promise that our berberine HCl powder complies with USP, EP, and CP standards, ensuring smooth entry to your target markets.